Even infants have excellent innate immune responses. Innate responses to infection occur rapidly and reliably. These cells include neutrophils, monocytes, natural killer (NK) cells, and a set of proteins known as the complement proteins. Innate immune responses are those that rely on cells that require no additional training to do their jobs. There are two broad categories of immune responses: innate and adaptive. To better understand the forms of PI, it’s helpful to know about the organization and maturation of the immune system. Some affect a single cell or protein of the immune system, and others may affect two or more components of the immune system. Some are relatively common, while others are quite rare. Primary immunodeficiency, or PI, are a group of disorders caused by defects in immune function that are inherent to the cells and proteins of the immune system. Some immune proteins circulate in the bloodstream, while others are made by immune cells and act on the organs and tissues near where the proteins are produced. The proteins may be made by immune cells or other organs such as the liver. Lymph nodes and the spleen provide structures that facilitate cell-to-cell communication. Cells travel through the bloodstream or in specialized vessels called lymphatics. Instead, the immune system is dispersed throughout the body to provide rapid responses to infection. These cells and proteins do not form a single organ like the heart or liver. The immune system is a wonderful collaboration between cells and proteins that work together to provide defense against infection. Each element performs a specific task aimed at recognizing and/or reacting against foreign material (germs). The immune system is composed of a variety of different cell types and proteins.
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